A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
Comparative assessment of potential human health impacts is a critical step in evaluating both chemical alternatives and existing products on the market. Most alternatives assessments are conducted on a chemical-by-chemical basis and it is seldom acknowledged that humans are exposed to complex products, not individual substances.
IN PRESS: Grouping of UVCB substances for chemical composition-based read-across using ion mobility mass spectrometry
Grimm FA, Russell WK, Luo Y-S, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. Grouping of UVCB substances for chemical composition-based read-across using ion mobility mass spectrometry. Env Sci Technol (in press)
Category approaches and ‘read-across’ in regulatory programmes
A new approach to evaluating the toxicological effects of petroleum substances by making use of existing test data aims to reduce, and eventually eliminate, the use of animals for toxicity testing. Coming soon.