An assessment of the reproductive toxicity of gasoline vapour

Report no. 00/53: The reproductive toxicity of gasoline vapour in rats was studied in order to generate relevant toxicity information for gasoline in humans via the inhalation route. The two generation study was designed and conducted according to international guidelines.

Exposure levels were 0 and approximately 5000, 10.000 and 20.000 milligram per cubic metre. No treatment-related adverse effects relevant to humans were observed.It was concluded that the No-Observed-Adverse-Effect-Level for reproductive toxicity in rats in this study was 20 000 milligram per cubic metre.