19 May 2016

Assessment of petroleum streams for thyroid toxicity

The thyroid gland, and its associated endocrine hormones, is a growing area of interest in regulatory toxicology due to its important role in metabolism, growth and development. This report presents a review of the toxicology data on chemically complex petroleum streams for thyroid hormone effects.


  • 19 petroleum streams were assessed for thyroid effects, from 349 animal studies;
  • 3 studies found effects related to thyroid toxicity, related to high aromatic content;
  • Two human studies reported significant but weak associations with thyroid cancer;
  • The 19 petroleum streams presented a low potential for thyroid effects or toxicity.
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