Public Health England is an executive agency of the UK Department of Health with responsibility for all aspects of public health in England. PHE combines public health and scientific expertise, research and emergency planning within the organisation. PHE remit covers infectious disease, hazardous chemicals and radiation. The Centre for Radiation, Chemical & Environmental Hazards (CRCE) provides all the specialist research and advice on chemical and radiological issues within PHE.
CRCE has expertise in toxicology (applied and basic mechanistic understanding) exposomics, transcriptomics, biomathematics, biostatistics and bioinformatics. This expertise is applied in emergency responses, chemical advice, risk assessment, support for expert government committees and peer reviewed research. In all these undertakings CRCE collaborates closely with a number of national and international institutions. In particular, CRCE has strong links with the European Commission, the World Health Organization (WHO), OECD, US EPA, Environment Canada, the Japan Centre for the Validation of Alternative Methods (JaCVAM), the United Nations Environment and Development Programmes, European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), American Association of Poison Control Centres (AAPCC) and many others.
The leading PI is Prof. Tim Gant who has extensive experience in transcriptomics and bioinformatics for chemical hazard profiling and mechanistic understanding evidenced by the publication record. He is a European Registered Toxicologist, worked in academia and government and has significant experience in the application of toxicology to advance public health. He brings to the project competence in toxicology, public health, toxicogenomics, bioinformatics, exposure science and chemistry.