North Carolina State University is one of the two flagship research institutions of the University of North Carolina system, with 9 major colleges and schools and over 31,000 students. The University is widely renowned as a trail-blazing national model for research in the public interest and for university-private-government interactions. Of particular relevance are partnerships with the National Institute of Environmental Health Sciences (NIEHS), and the US Environmental Protection Agency (EPA), fostering a dynamic atmosphere for toxicological research and data from high-throughput screening.

The Bioinformatics Research Center (BRC) at NCSU, directed by WP4 investigator Wright, is an interdisciplinary center devoted to research at the interfaces of quantitative and biological sciences, with strengths in statistical methods applied to toxicological problems. BRC computing includes access to campus-wide high-performance computing, as well as a state-of-the-art Linux cluster specific to the BRC, with nearly a 1000-job capacity and several nodes appropriate for computation requiring massive memory. The cluster is maintained by a full-time administrator, is continually expandable, and the software environment includes several packages for chem-informatics and genetic and toxicological computing.

The principal investigator is Fred Wright, Ph.D. Dr. Wright is a statistical geneticist with a decade of experience working with toxicogenomic data, with an emphasis on ‘omics profiling and director of the NCSU Bioinformatics Research Center. His past work in a number of areas, including methodology for expression profiling, genetic association, and gene set analysis, as well as theoretical work in high-dimensional analysis, give Wright a very broad perspective to synthesize and integrate data for WP5. In addition, Wright has extensive experience communicating ideas and practical concepts to risk assessors and various stakeholders, ensuring that the activities in WP4 remain relevant and accessible to the community.

Wright is director of the Biostatistics and Bioinformatics Core of the UNC-NCSU Superfund Research Program grant from the National Institute of Environmental Health Sciences, and was past director of a similar core for the University of North Carolina Center for Environmental Health Susceptibility.