Objectives

Cat-App objectives:

 

  • Cat-App was initiated with the aim to minimize the need for testing in vertebrate animals under regulatory programmes. This is achieved by grouping petroleum substances (PS) to make most optimal use of the toxicological information on PS by read-across of the available data within- and (where needed and justified) between these groups. A framework will be developed for grouping based on chemical-biological properties combining multiple streams of information comprising PS production type/refining process, physical-chemical properties, chemical analytical profiles, existing (eco-)toxicological data and a comprehensive array of biological responses in a broad spectrum of in vitro systems.
  • Direct implementation of the Cat-App framework in the Concawe REACH strategy by applying the approach and submitting the data in the petroleum REACH dossiers, in order to fill datagaps with the already existing in vivo toxicological data on PS and develop a pragmatic and informed testing approach only as a last resort when read across to fill data gaps is not possible. This strategy will eventually address mandatory human health hazard endpoints under REACH while significantly reducing the use of vertebrate animals for toxicity testing without underestimating hazard.
  • Inform a broad spectrum of stakeholders globally (commercial entities, regulatory agencies and non-governmental organizations) concerned with public health and wellbeing, to promote application of the Cat-App framework which is expected to eventually have a wide and diverse applicability domain.